首页 > 一抗 > UGT1A1 Antibody

UGT1A1 (基因名), UDP-glucuronosyltransferase 1-1 (蛋白名), ud11_human.

产品名称:

UGT1A1 Antibody

货号:

P12952Rb-h

商标:

EIAab^®

监管等级:

RUO

别名:

Bilirubin-specific UDPGT isozyme 1, UDP-glucuronosyltransferase 1-A, UDP-glucuronosyltransferase 1A1, hUG-BR1, UGT-1A, UDPGT 1-1, GNT1, UGT1

序列号:

P22309

反应性:

human

免疫原:

Recombinant human UGT1A1 protein ( R12952h )

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

规格 & 价格:

关注

Human UGT1A1 Polyclonal Antibody

邮箱 *

消息 *

Please 登录.

产品说明书

数据表:

MSDS:

在线询价

数据
文献
序列 / 3D
视频
常见问题解答
反馈墙 (0)

R&D 技术数据

UGT1A1 was detected in immersion fixed paraffinembedded sections of human liver using Rabbit AntiUGT1A1 Polyclonal Antibodyat 1:300.

通用注释

亚单元:

Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10. Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

功能:

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.

亚细胞位置:

Isoform 2 Microsome Endoplasmic reticulum

数据库链接

UniGene:

Hs.554822

STRING:

9606.ENSP00000304845

KEGG:

hsa:54658

MIM:

143500

Pfam: