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TJP1 (基因名), Tight junction protein ZO-1 (蛋白名), zo1_human.
产品名称:

TJP1 Antibody

货号:

P9600Rb-h

商标:
EIAab®
监管等级:
别名:

Tight junction protein 1, Zona occludens protein 1, Zonula occludens protein 1, ZO1

序列号:
Q07157
反应性:
human
免疫原:
Recombinant human TJP1 protein ( R9600h )
形态:
Liquid
存储说明:
4℃ for frequent use, -20℃ to -70℃ for 6 months
缓冲液:
0.1M×PBS,50% glycerol,pH7.5
浓度:
200ug/ml
纯化方式:
Immunogen affinity purified
克隆性:
Polyclonal
亚型:
Rabbit IgG
应用:
推荐产品:
研究领域:
-
Human TJP1 Polyclonal Antibody
规格 & 价格: cart
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Human TJP1 Polyclonal Antibody
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产品说明书
数据表: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
TJP1 detects TJP1 protein at cell membrane and cytoplasm in mouse intestine by immunohistochemical analysis. antibody diluted at 1:300.
通用注释


亚单元:
Homodimer, and heterodimer with TJP2/ZO-2 and TJP3/ZO-3 (PubMed:17928286, PubMed:16737969). Interacts with OCLN, CALM, claudins, CGN/cingulin, CXADR, GJA12, GJD3 and UBN1 (PubMed:11734628, PubMed:12023291, PubMed:12154091, PubMed:15183511, PubMed:18823282, PubMed:20200156). Interacts (via ZU5 domain) with CDC42BPB and MYZAP (PubMed:20093627, PubMed:21240187). Interacts (via PDZ domain) with GJA1 (PubMed:18636092). Interacts (via PDZ domains) with ANKRD2 (PubMed:22016770). Interacts with BVES (via the C-terminus cytoplasmic tail) (By similarity). Interacts with HSPA4 and KIRREL1 (By similarity). Interacts with DLL1 (By similarity). Interacts with USP53 (via the C-terminal region).


功能:
The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.


亚细胞位置:
Cell membrane Peripheral membrane protein Cytoplasmic side Cell junction Tight junction Cell junction Cell junction Gap junction Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact. Detected at the leading edge of migrating and wounded cells.


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