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ABRAXAS1 (基因名), BRCA1-A complex subunit Abraxas 1 (蛋白名), abrx1_chick.
产品名称:

Chicken ABRAXAS1/ BRCA1-A complex subunit Abraxas 1 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Coiled-coil domain-containing protein 98, Protein FAM175A, RCJMB04_33o10, ABRA1, CCDC98, FAM175A

序列号:
Q5ZHS0
来源:
E.coli
种属:
Chicken
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Chicken ABRAXAS1 Protein
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Chicken ABRAXAS1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Component of the BRCA1-A complex. Component of the BRISC complex. Homodimer. Interacts directly (when phosphorylated at Ser-402) with BRCA1. The phosphorylated homodimer can interact directly with two BRCA1 chains, giving rise to a heterotetramer (By similarity).


功能:
Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.


亚细胞位置:
Nucleus Localizes at sites of DNA damage at double-strand breaks (DSBs).


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