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AICDA (基因名), Single-stranded DNA cytosine deaminase (蛋白名), aicda_bovin.
产品名称:

Bovine AICDA/ Single-stranded DNA cytosine deaminase Recombinant Protein
活化诱导胞嘧啶核苷脱氨酶

货号:

R14184b

商标:
EIAab®
监管等级:
别名:

Activation-induced cytidine deaminase, Cytidine aminohydrolase, AID

序列号:
Q2PT36
来源:
E.coli
种属:
Bovine
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Epigenetics
Bovine AICDA Protein
规格 & 价格: cart
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Bovine AICDA Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
Interacts with CTNNBL1; the interaction is important for the immunoglobulin switch activity of AICDA. Interacts (via its NLS) with KPNA1. Interacts with PKA/PRKACA and PRKAR1A/PKR1. Interacts with SUPT6H, TRIM28 and NCL.


功能:
Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.


亚细胞位置:
Nucleus Cytoplasm Predominantly cytoplasmic but shuttles between the nucleus and the cytoplasm.


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