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ARC (基因名), Activity-regulated cytoskeleton-associated protein (蛋白名), arc_chick.
产品名称:

Chicken ARC/ Activity-regulated cytoskeleton-associated protein Recombinant Protein
细胞骨架活性调节蛋白

货号:

R7736c

商标:
EIAab®
监管等级:
别名:

Activity-regulated gene 3.1 protein homolog, ARC/ARG3.1

序列号:
Q8AWC3
来源:
E.coli
种属:
Chicken
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Chicken ARC Protein
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Chicken ARC Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
Homooligomer; homooligomerizes into virion-like capsids.


功能:
Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material.


亚细胞位置:
Extracellular vesicle membrane Lipid-anchor Cell junction Synapse Postsynaptic cell membrane Lipid-anchor Cell junction Synapse Cell junction Synapse Postsynaptic cell membrane Postsynaptic density Early endosome membrane Cell projection Dendrite Cytoplasm Cytoskeleton Cytoplasm Cell cortex Cell projection Dendritic spine Forms virion-like extracellular vesicles that are released from neurons. Enriched in postsynaptic density of dendritic spines. Accumulates at weaker synapses may be required to prevent their undesired enhancement. Associated with the cell cortex of neuronal soma and dendrites.


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