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ATG7 (基因名), Ubiquitin-like modifier-activating enzyme ATG7 (蛋白名), atg7_chick.
产品名称:

Chicken ATG7/ Ubiquitin-like modifier-activating enzyme ATG7 Recombinant Protein

货号:

R2476c

商标:
EIAab®
监管等级:
别名:

ATG12-activating enzyme E1 ATG7, Autophagy-related protein 7, APG7-like, RCJMB04_8l10, APG7L

序列号:
Q5ZKY2
来源:
E.coli
种属:
Chicken
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Chicken ATG7 Protein
规格 & 价格: cart
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Chicken ATG7 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
Homodimer. Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5.


功能:
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.


亚细胞位置:
Cytoplasm Preautophagosomal structure


该产品尚未在任何出版物中被引用。
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