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COMP (基因名), Cartilage oligomeric matrix protein (蛋白名), comp_bovin.
产品名称:

Bovine COMP/ Cartilage oligomeric matrix protein Recombinant Protein
软骨寡聚基质蛋白

货号:

R1197b

商标:
EIAab®
监管等级:
别名:

COMP

序列号:
P35445
来源:
E.coli
种属:
Bovine
标签:
His
序列:
526-756aa
预估分子量:
25.41 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Bovine COMP Protein
规格 & 价格: cart
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Bovine COMP Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Bovine COMP Protein
Recombinant bovine COMP protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
通用注释


亚单元:
Pentamer; disulfide-linked. Exists in a more compact conformation in the presence of calcium and shows a more extended conformation in the absence of calcium. Interacts with ITGB3, ITGA5 and FN1. Binding to FN1 requires the presence of divalent cations (Ca(2+), Mg(2+) or Mn(2+)). The greatest amount of binding is seen in the presence of Mn(2+). Interacts with MATN3, MATN4 and ACAN. Binds heparin, heparan sulfate and chondroitin sulfate. EDTA dimishes significantly its binding to ACAN and abolishes its binding to MATN3, MATN4 and chondroitin sulfate. Interacts with collagen I, II and IX and interaction with these collagens is dependent on the presence of zinc ions (By similarity). Interacts with MATN1. Interacts with ADAMTS12. Interacts with ITGA7.


功能:
May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.


亚细胞位置:
Secreted Extracellular space Extracellular matrix


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