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首页  >  重组蛋白  >  Pig CUBN Recombinant Protein
CUBN (基因名), Cubilin (蛋白名), cubn_pig.
产品名称:

Pig CUBN/ Cubilin Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Intrinsic factor-cobalamin receptor, IFCR

序列号:
F1RWC3
来源:
E.coli
种属:
Pig
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Pig CUBN Protein
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Pig CUBN Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Interacts with AMN. Component of the cubam complex composed of one CUBN trimer and one AMN chain (PubMed:30523278). The cubam complex can dimerize (PubMed:30523278). Interacts with LRP2 in a dual-receptor complex in a calcium-dependent manner. Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with LRP1 and PID1/PCLI1 (By similarity).


功能:
Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.


亚细胞位置:
Apical cell membrane Peripheral membrane protein Cell membrane Peripheral membrane protein Membrane Coated pit Endosome Lysosome membrane Peripheral membrane protein Lacks a transmembrane domain and depends on interaction with AMN for location at the plasma membrane (By similarity). Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells (By similarity).


该产品尚未在任何出版物中被引用。
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