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DCLRE1B (基因名), 5' exonuclease Apollo (蛋白名), dcr1b_chick.
产品名称:

Chicken DCLRE1B/ 5' exonuclease Apollo Recombinant Protein

货号:

R2633c

商标:
EIAab®
监管等级:
别名:

DNA cross-link repair 1B protein, SNM1 homolog B, SNM1B

序列号:
Q5QJC3
来源:
E.coli
种属:
Chicken
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Chicken DCLRE1B Protein
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Chicken DCLRE1B Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
Interacts with TERF2; the interaction is direct.


功能:
5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways (By similarity). May be required for DNA interstrand cross-link repair.


亚细胞位置:
Chromosome Telomere Nucleus


该产品尚未在任何出版物中被引用。
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