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DNA2 (基因名), DNA replication ATP-dependent helicase/nuclease DNA2 (蛋白名), dna2_chick.
产品名称:

Chicken DNA2/ DNA replication ATP-dependent helicase/nuclease DNA2 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

DNA replication ATP-dependent helicase-like homolog, RCJMB04_11a16, DNA2L

序列号:
Q5ZKG3
来源:
E.coli
种属:
Chicken
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Chicken DNA2 Protein
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Chicken DNA2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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通用注释


亚单元:
N/A


功能:
Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function.


亚细胞位置:
Nucleus Mitochondrion


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