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EFNA2 (基因名), Ephrin-A2 (蛋白名), efna2_human.
产品名称:

Human EFNA2/ Ephrin-A2 Recombinant Protein
Ephrin-A2

货号:

R0301h

商标:
EIAab®
监管等级:
别名:

EPH-related receptor tyrosine kinase ligand 6, HEK7 ligand, LERK-6, HEK7-L, EPLG6, LERK6

序列号:
O43921
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human EFNA2 Protein
规格 & 价格: cart
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Human EFNA2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 19p13.3 by HGNC 19p13.3 by Entrez Gene 19p13.3 by Ensembl
EFNA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Binds to the receptor tyrosine kinases EPHA3, EPHA4 and EPHA5. Interacts with EPHA8; activates EPHA8.


功能:
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.


亚细胞位置:
Cell membrane Lipid-anchor GPI-anchor


该产品尚未在任何出版物中被引用。

[1].
"Characterization of the genes for mouse LERK-3/Ephrin-A3 (Epl3), mouse LERK-4/Ephrin-A4 (Epl4), and human LERK-6/Ephrin-A2 (EPLG6): conservation of intron/exon structure."

[2].
"Cloning, chromosal mapping, and tissue expression of the gene encoding the human Eph-family kinase ligand ephrin-A2."

[3].
"Structural plasticity of eph receptor A4 facilitates cross-class ephrin signaling."

[4].
"Elf-1 binds to GGAA elements on the FcRgamma promoter and represses its expression."

[5].
"The DNA sequence and biology of human chromosome 19."

[6].
"Defective production of functional 98-kDa form of Elf-1 is responsible for the decreased expression of TCR zeta-chain in patients with systemic lupus erythematosus."

[7].
"Regulated cleavage of a contact-mediated axon repellent."

[8].
"Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro."

[9].
"Diagnostic and prognostic value of tissue and circulating levels of Ephrin-A2 in prostate cancer."

[10].
"CIB1 synergizes with EphrinA2 to regulate Kaposi's sarcoma-associated herpesvirus macropinocytic entry in human microvascular dermal endothelial cells."
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