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Enpp1 (基因名), Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (蛋白名), enpp1_rat.
产品名称:

Rat Enpp1/ Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Recombinant Protein
外核苷酸焦磷酸酶/磷酸二酯酶家族成员1

货号:

R1032r

商标:
EIAab®
监管等级:
别名:

Phosphodiesterase I/nucleotide pyrophosphatase 1, Plasma-cell membrane glycoprotein PC-1, E-NPP 1, Npps, Pc1, Pdnp1

序列号:
Q924C3
来源:
E.coli
种属:
Rat
标签:
His
序列:
Recombinant protein
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Metabolism
Rat Enpp1 Protein
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Rat Enpp1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
Homodimer. The secreted form is monomeric. Interacts with INSR.


功能:
By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity.


亚细胞位置:
Cell membrane Single-pass type II membrane protein Basolateral cell membrane Single-pass type II membrane protein Secreted Targeted to the basolateral membrane in polarized epithelial cells and in hepatocytes, and to matrix vesicles in osteoblasts. In bile duct cells and cancer cells, located to the apical cytoplasmic side. The proteolytically processed form is secreted.


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