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EPCAM (基因名), Epithelial cell adhesion molecule (蛋白名), epcam_human.
产品名称:

Human EPCAM/ Epithelial cell adhesion molecule Recombinant Protein
上皮细胞粘附分子

货号:

R1283h

商标:
EIAab®
监管等级:
别名:

Adenocarcinoma-associated antigen, Cell surface glycoprotein Trop-1, Epithelial cell surface antigen, Epithelial glycoprotein, Epithelial glycoprotein 314, KS 1/4 antigen, KSA, Major gastrointestinal tumor-associated protein GA733-2, Tumor-associated calcium signal transducer 1, EGP, EGP314, CD326, Ep-CAM, GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1

序列号:
P16422
来源:
E.coli
种属:
Human
标签:
His
序列:
78-258aa
预估分子量:
19.91 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cell Biology
Human EPCAM Protein
规格 & 价格: cart
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human EPCAM Protein
Recombinant human EPCAM protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 2p21 by HGNC 2p21 by Entrez Gene 2p21 by Ensembl
EPCAM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Monomer. Interacts with phosphorylated CLDN7.


功能:
May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.


亚细胞位置:
Lateral cell membrane Single-pass type I membrane protein Cell junction Tight junction Colocalizes with CLDN7 at the lateral cell membrane and tight junction.


该产品尚未在任何出版物中被引用。

[1].
"Retroposition in a family of carcinoma-associated antigen genes."

[2].
"Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1."

[3].
"Glycosylation is crucial for stability of tumour and cancer stem cell antigen EpCAM."

[4].
"Identification of EpCAM as the gene for congenital tufting enteropathy."

[5].
"The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7."

[6].
"The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP."

[7].
"The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation."

[8].
"Determination of disulfide bond assignments and N-glycosylation sites of the human gastrointestinal carcinoma antigen GA733-2 (CO17-1A, EGP, KS1-4, KSA, and Ep-CAM)."

[9].
"Characterization of epithelial cell adhesion molecule as a surface marker on undifferentiated human embryonic stem cells."

[10].
"Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"."
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