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F12 (基因名), Coagulation factor XII (蛋白名), fa12_human.
产品名称:

Human F12/ Coagulation factor XII Recombinant Protein
活化凝血因子Ⅻ

货号:

R0694h

商标:
EIAab®
监管等级:
别名:

Hageman factor, HAF

序列号:
P00748
来源:
E.coli
种属:
Human
标签:
His
序列:
373-615aa
预估分子量:
26.73 kDa (monomer)
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human F12 Protein
规格 & 价格: cart
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Human F12 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 5q35.3 by HGNC 5q35.3 by Entrez Gene 5q35.3 by Ensembl
F12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with HRG; the interaction, which is enhanced in the presence of zinc ions and inhibited by heparin-binding, inhibits factor XII autoactivation and contact-initiated coagulation.


功能:
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.


亚细胞位置:
Secreted


该产品尚未在任何出版物中被引用。

[1].
"Accumulation of gene polymorphisms related to plaque disruption and thrombosis is associated with cerebral infarction in subjects with type 2 diabetes."

[2].
"Sequence variation and genetic evolution at the human F12 locus: mapping quantitative trait nucleotides that influence FXII plasma levels."

[3].
"The functional promoter polymorphism of the coagulation factor XII gene is not associated with peripheral arterial disease."

[4].
"The effect of nine common polymorphisms in coagulation factor genes (F2, F5, F7, F12 and F13 ) on the effectiveness of statins: the GenHAT study."

[5].
"Gender differences in genetic risk profiles for cardiovascular disease."

[6].
"Coagulation factor XII (FXII) activity, activated FXII, distribution of FXII C46T gene polymorphism and coronary risk."

[7].
"Increased activity of coagulation factor XII (Hageman factor) causes hereditary angioedema type III."

[8].
"Missense mutations in the coagulation factor XII (Hageman factor) gene in hereditary angioedema with normal C1 inhibitor."

[9].
"Synergistic association between hypercholesterolemia and the C46T factor XII polymorphism for developing premature myocardial infarction."

[10].
"The C46T polymorphism of the coagulation factor XII gene and idiopathic recurrent miscarriage."
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