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FANCM (基因名), Fanconi anemia group M protein (蛋白名), fancm_chick.
产品名称:

Chicken FANCM/ Fanconi anemia group M protein Recombinant Protein

货号:

R14596c

商标:
EIAab®
监管等级:
别名:

ATP-dependent RNA helicase FANCM, Fanconi anemia-associated polypeptide of 250 kDa, Protein Hef ortholog, FAAP250, Protein FACM

序列号:
A0A1D5PRR9
来源:
E.coli
种属:
Chicken
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Chicken FANCM Protein
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Chicken FANCM Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
Component of the Fanconi anemia (FA) core complex. The FA core complex associates with Bloom syndrome (BLM) complex. This supercomplex between FA and BLM complexes has been called BRAFT.


功能:
DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116434, PubMed:19465393). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork (By similarity). This activity is strongly stimulated in the presence of CENPS and CENPX (By similarity). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (By similarity). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA.


亚细胞位置:
Nucleus


该产品尚未在任何出版物中被引用。
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