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FBN2 (基因名), Fibrillin-2 (蛋白名), fbn2_human.
产品名称:

Human FBN2/ Fibrillin-2 Recombinant Protein
原纤维蛋白2

货号:

R8805h

商标:
EIAab®
监管等级:
序列号:
P35556
来源:
E.coli
种属:
Human
标签:
His
序列:
Recombinant protein
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cardiovascular
Human FBN2 Protein
规格 & 价格: cart
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Human FBN2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 5q23.3 by HGNC 5q23.3 by Entrez Gene 5q23.3 by Ensembl
FBN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with BMP2, BMP4, BMP7, BMP10 and GDF5 (PubMed:18339631). Interacts with MFAP2 and MFAP5 (PubMed:15131124). Interacts with ADAMTSL5 (PubMed:23010571). Interacts with MFAP4 (PubMed:26601954).


功能:
Fibrillin-2: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.


亚细胞位置:
Secreted Extracellular space Extracellular matrix


该产品尚未在任何出版物中被引用。

[1].
"Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices."

[2].
"Comprehensive clinical and molecular assessment of 32 probands with congenital contractural arachnodactyly: report of 14 novel mutations and review of the literature."

[3].
"Association analysis of genes involved in the maintenance of the integrity of the extracellular matrix with intracranial aneurysms in a Japanese cohort."

[4].
"MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils."

[5].
"Association of positional and functional candidate genes FGF1, FBN2, and LOX on 5q31 with intracranial aneurysm."
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