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FBXO38 (基因名), F-box only protein 38 (蛋白名), fbx38_human.
产品名称:

Human FBXO38/ F-box only protein 38 Recombinant Protein
只含F-box蛋白38

货号:

R3942h

商标:
EIAab®
监管等级:
别名:

SP329

序列号:
Q6PIJ6
来源:
E.coli
种属:
Human
标签:
His
序列:
501-790aa
预估分子量:
31.9 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human FBXO38 Protein
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Human FBXO38 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human FBXO38 Protein
Recombinant human FBXO38 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 5q32 by HGNC 5q32 by Entrez Gene 5q32 by Ensembl
FBXO38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO38) composed of CUL1, SKP1, RBX1 and FBXO38 (Probable). Interacts with KLF7 (By similarity). Interacts with PDCD1/PD-1 (PubMed:30487606).


功能:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity).


亚细胞位置:
Cytoplasm Cytosol Nucleus Accumulates predominantly in the cytosol. Exported from the nucleus in a XPO1/CRM1-dependent manner.


该产品尚未在任何出版物中被引用。

[1].
"A dominant mutation in FBXO38 causes distal spinal muscular atrophy with calf predominance."

[2].
"Genome-wide searching of rare genetic variants in WTCCC data."

[3].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[4].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[5].
"Large-scale cDNA transfection screening for genes related to cancer development and progression."
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