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FCGRT (基因名), IgG receptor FcRn large subunit p51 (蛋白名), fcgrn_human.
产品名称:

Human FCGRT/ IgG receptor FcRn large subunit p51 Recombinant Protein
免疫球蛋白受体FcRn的大亚基p51

货号:

R13790h

商标:
EIAab®
监管等级:
别名:

IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor, FcRn, FCRN

序列号:
P55899
来源:
E.coli
种属:
Human
标签:
His
序列:
24-297aa
预估分子量:
30.14 kDa (monomer)
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Immunology
Human FCGRT Protein
规格 & 价格: cart
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Human FCGRT Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 19q13.33 by HGNC 19q13.33 by Entrez Gene 19q13.33 by Ensembl
FCGRT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer.


功能:
Binds to the Fc region of monomeric immunoglobulins gamma (PubMed:7964511, PubMed:10933786). Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (By similarity). Possible role in transfer of immunoglobulin G from mother to fetus (PubMed:7964511).


亚细胞位置:
Cell membrane Single-pass type I membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Association between polymorphisms in the FCGRT gene and lupus nephritis in Chinese patients."

[2].
"Cloning and analysis of the gene encoding the human neonatal Fc receptor."

[3].
"Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,)."

[4].
"The human gene encoding the heavy chain of the major histocompatibility complex class I-like Fc receptor (FCGRT) maps to 19q13.3."

[5].
"A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus."

[6].
"Risk of meningioma and common variation in genes related to innate immunity."

[7].
"Polymorphisms in innate immunity genes and risk of childhood leukemia."

[8].
"FcRn binding properties of an abnormal truncated analbuminemic albumin variant."

[9].
"Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding."

[10].
"Importance of neonatal FcR in regulating the serum half-life of therapeutic proteins containing the Fc domain of human IgG1: a comparative study of the affinity of monoclonal antibodies and Fc-fusion proteins to human neonatal FcR."
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