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FCN1 (基因名), Ficolin-1 (蛋白名), fcn1_human.
产品名称:

Human FCN1/ Ficolin-1 Recombinant Protein
Ficolin-1

货号:

R1506h

商标:
EIAab®
监管等级:
别名:

Collagen/fibrinogen domain-containing protein 1, Ficolin-A, Ficolin-alpha, M-ficolin, FCNM

序列号:
O00602
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Immunology
Human FCN1 Protein
规格 & 价格: cart
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Human FCN1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 9q34.3 by HGNC 9q34.3 by Entrez Gene 9q34.3 by Ensembl
FCN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homotrimer (PubMed:17897951). Interacts with elastin/ELN. Interacts (via Fibrinogen C-terminal domain) with FFAR2. Interacts with CRP; may regulate monocyte activation by FCN1.


功能:
Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.


亚细胞位置:
Secreted Cell membrane Peripheral membrane protein Extracellular side Found on the monocyte and granulocyte surface (PubMed:20400674).


该产品尚未在任何出版物中被引用。

[1].
"Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin."

[2].
"Trivalent recognition unit of innate immunity system: crystal structure of trimeric human M-ficolin fibrinogen-like domain."

[3].
"Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis."

[4].
"Human ficolin: cDNA cloning, demonstration of peripheral blood leucocytes as the major site of synthesis and assignment of the gene to chromosome 9."

[5].
"Characterization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1."

[6].
"Characteristics and biological variations of M-ficolin, a pattern recognition molecule, in plasma."

[7].
"Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain."

[8].
"Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense."

[9].
"M-ficolin in the neonatal period: Associations with need for mechanical ventilation and mortality in premature infants with necrotising enterocolitis."

[10].
"Synergy between ficolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition."
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