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FCN3 (基因名), Ficolin-3 (蛋白名), fcn3_human.
产品名称:

Human FCN3/ Ficolin-3 Recombinant Protein
胶原凝集素3

货号:

R1903h

商标:
EIAab®
监管等级:
别名:

Collagen/fibrinogen domain-containing lectin 3 p35, Collagen/fibrinogen domain-containing protein 3, Hakata antigen, FCNH, HAKA1

序列号:
O75636
来源:
E.coli
种属:
Human
标签:
His
序列:
24-299aa
预估分子量:
30.36 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human FCN3 Protein
规格 & 价格: cart
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Human FCN3 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human FCN3 Protein
Recombinant human FCN3 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 1p36.11 by HGNC 1p36.11 by Entrez Gene 1p36.11 by Ensembl
FCN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homotrimer (PubMed:17215869). May form an octadecamer consisting of an elementary trimer unit. Does not interact with fibronectin, elastin or zymosan. Interacts with MASP1 and MASP2.


功能:
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.


亚细胞位置:
Secreted Found in blood plasma, bronchus, alveolus and bile duct.


该产品尚未在任何出版物中被引用。

[1].
"Exploring the role of polymorphisms in ficolin genes in respiratory tract infections in children."

[2].
"Structural insights into the innate immune recognition specificities of L- and H-ficolins."

[3].
"Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis."

[4].
"Activation of the lectin complement pathway by H-ficolin (Hakata antigen)."

[5].
"Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile."

[6].
"Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family."

[7].
"Immunodeficiency associated with FCN3 mutation and ficolin-3 deficiency."

[8].
"Residue Lys57 in the collagen-like region of human L-ficolin and its counterpart Lys47 in H-ficolin play a key role in the interaction with the mannan-binding lectin-associated serine proteases and the collectin receptor calreticulin."

[9].
"Serum levels of ficolin-3 (Hakata antigen) in patients with systemic lupus erythematosus."

[10].
"Comparative study of the human ficolins reveals unique features of Ficolin-3 (Hakata antigen)."
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