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FGF8 (基因名), Fibroblast growth factor 8 (蛋白名), fgf8_human.
产品名称:

Human FGF8/ Fibroblast growth factor 8 Recombinant Protein
纤维母细胞生长因子8

货号:

R2137h

商标:
EIAab®
监管等级:
别名:

Androgen-induced growth factor, Heparin-binding growth factor 8, AIGF, HBGF-8, FGF-8, AIGF

序列号:
P55075
来源:
E.coli
种属:
Human
标签:
His
序列:
23-233aa
预估分子量:
23.21 kDa (monomer)
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human FGF8 Protein
规格 & 价格: cart
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Human FGF8 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 10q24.32 by HGNC 10q24.32 by Entrez Gene 10q24.32 by Ensembl
FGF8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.


功能:
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (PubMed:16384934, PubMed:16597617, PubMed:8663044). Plays a role in neurite outgrowth in hippocampal cells (PubMed:21576111).


亚细胞位置:
Secreted


该产品尚未在任何出版物中被引用。

[1].
"Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice."

[2].
"FGFR2, FGF8, FGF10 and BMP7 as candidate genes for hypospadias."

[3].
"Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain."

[4].
"Structure and sequence of human FGF8."

[5].
"The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells."

[6].
"Molecular cloning and characterization of human FGF8 alternative messenger RNA forms."

[7].
"Assignment of FGF8 to human chromosome 10q25-q26: mutations in FGF8 may be responsible for some types of acrocephalosyndactyly linked to this region."

[8].
"Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties."

[9].
"Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia."

[10].
"FGF-8 is involved in bone metastasis of prostate cancer."
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