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FLG (基因名), Filaggrin (蛋白名), fila_human.
产品名称:

Human FLG/ Filaggrin Recombinant Protein
丝聚蛋白

货号:

R1186h

商标:
EIAab®
监管等级:
序列号:
P20930
来源:
E.coli
种属:
Human
标签:
His
序列:
1-240aa
预估分子量:
26.4 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Signal Transduction
Human FLG Protein
规格 & 价格: cart
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Human FLG Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 1q21.3 by HGNC 1q21.3 by Entrez Gene 1q21.3 by Ensembl
FLG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
N/A


功能:
Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.


亚细胞位置:
Cytoplasmic granule In the stratum granulosum of the epidermis, localized within keratohyalin granules (PubMed:1429717). In granular keratinocytes and in lower corneocytes, colocalizes with calpain-1/CAPN1 (PubMed:21531719).


该产品尚未在任何出版物中被引用。

[1].
"Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis."

[2].
"Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations."

[3].
"Human leukocyte antigen (DR1)-DQB1*0501 and (DR15)-DQB1*0602 haplotypes are associated with humoral responses to early food allergens in children."

[4].
"Elder siblings enhance the effect of filaggrin mutations on childhood eczema: results from the 2 birth cohort studies LISAplus and GINIplus."

[5].
"Chromosome 11q13.5 variant associated with childhood eczema: an effect supplementary to filaggrin mutations."

[6].
"Carrier status for the common R501X and 2282del4 filaggrin mutations is not associated with hearing phenotypes in 5,377 children from the ALSPAC cohort."

[7].
"Filaggrin null mutations in childhood atopic dermatitis among the Chinese."

[8].
"Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum."

[9].
"Filaggrin haploinsufficiency is highly penetrant and is associated with increased severity of eczema: further delineation of the skin phenotype in a prospective epidemiological study of 792 school children."

[10].
"FLG mutation p.Lys4021X in the C-terminal imperfect filaggrin repeat in Japanese patients with atopic eczema."
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