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FKBP8 (基因名), Peptidyl-prolyl cis-trans isomerase FKBP8 (蛋白名), fkbp8_human.
产品名称:

Human FKBP8/ Peptidyl-prolyl cis-trans isomerase FKBP8 Recombinant Protein
肽酰-脯氨酰顺反异构酶FKBP8

货号:

R11198h

商标:
EIAab®
监管等级:
别名:

38 kDa FK506-binding protein, FK506-binding protein 8, FKBPR38, Rotamase, 38 kDa FKBP, FKBP-8, PPIase FKBP8, FKBP38

序列号:
Q14318
来源:
E.coli
种属:
Human
标签:
His
序列:
Recombinant protein
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cardiovascular
Human FKBP8 Protein
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Human FKBP8 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 19p13.11 by HGNC 19p13.11 by Entrez Gene 19p13.11 by Ensembl
FKBP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCL2L1/BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation.


功能:
Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.


亚细胞位置:
Isoform 3 Mitochondrion membrane Single-pass membrane protein Cytoplasmic side


该产品尚未在任何出版物中被引用。

[1].
"Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs."

[2].
"Characterization of a Bcl-XL-interacting protein FKBP8 and its splice variant in human RPE cells."

[3].
"Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin."

[4].
"Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis."

[5].
"A charge-sensitive loop in the FKBP38 catalytic domain modulates Bcl-2 binding."

[6].
"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression."

[7].
"Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse."

[8].
"The Bcl-2 regulator FKBP38-calmodulin-Ca2+ is inhibited by Hsp90."

[9].
"Co-chaperone FKBP38 promotes HERG trafficking."

[10].
"Anchoring of the 26S proteasome to the organellar membrane by FKBP38."
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