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GAB2 (基因名), GRB2-associated-binding protein 2 (蛋白名), gab2_human.
产品名称:

Human GAB2/ GRB2-associated-binding protein 2 Recombinant Protein
GRB2-associated-binding蛋白2

货号:

R2740h

商标:
EIAab®
监管等级:
别名:

GRB2-associated binder 2, Growth factor receptor bound protein 2-associated protein 2, pp100, KIAA0571

序列号:
Q9UQC2
来源:
E.coli
种属:
Human
标签:
His
序列:
448-676aa
预估分子量:
25.19 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Human GAB2 Protein
规格 & 价格: cart
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Human GAB2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human GAB2 Protein
Recombinant human GAB2 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 11q14.1 by HGNC 11q14.1 by Entrez Gene 11q14.1 by Ensembl
GAB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with SHC1; may mediate interaction with receptors (By similarity). Interacts with SYK (By similarity). Interacts with PI-3 kinase. Interacts with GRB2 (via SH3 2 domain). Interacts (phosphorylated) with PTPN11. Interacts with TNFRSF11A (via cytoplasmic domain). Interacts (phosphorylated) with 14-3-3 family proteins SFN, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ; prevents interaction with GRB2 and attenuates GAB2 signaling. Interacts with HCK.


功能:
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.


亚细胞位置:
Cytoplasm Cell membrane


该产品尚未在任何出版物中被引用。

[1].
"Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors."

[2].
"Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2."

[3].
"GAB2 is not associated with late-onset Alzheimer's disease in Japanese."

[4].
"Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein."

[5].
"The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis."
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