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GAK (基因名), Cyclin-G-associated kinase (蛋白名), gak_human.
产品名称:

Human GAK/ Cyclin-G-associated kinase Recombinant Protein

货号:

R15637h

商标:
EIAab®
监管等级:
序列号:
O14976
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human GAK Protein
规格 & 价格: cart
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Human GAK Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 4p16.3 by HGNC 4p16.3 by Entrez Gene 4p16.3 by Ensembl
GAK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
N/A


功能:
Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.


亚细胞位置:
Cytoplasm Perinuclear region Golgi apparatus Trans-Golgi network Cell junction Focal adhesion Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions.


该产品尚未在任何出版物中被引用。

[1].
"Structure, expression, and chromosomal localization of human GAK."

[2].
"Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies."

[3].
"Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease."

[4].
"GAK, a regulator of clathrin-mediated membrane trafficking, localizes not only in the cytoplasm but also in the nucleus."

[5].
"GAK, a regulator of clathrin-mediated membrane traffic, also controls centrosome integrity and chromosome congression."

[6].
"Genomewide association study for susceptibility genes contributing to familial Parkinson disease."

[7].
"Canonical interaction of cyclin G associated kinase with adaptor protein 1 regulates lysosomal enzyme sorting."

[8].
"Recruitment dynamics of GAK and auxilin to clathrin-coated pits during endocytosis."

[9].
"Depletion of GAK/auxilin 2 inhibits receptor-mediated endocytosis and recruitment of both clathrin and clathrin adaptors."

[10].
"Identification of NPM-ALK interacting proteins by tandem mass spectrometry."
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