首页 > 重组蛋白 > Human GDF15 Recombinant Protein

GDF15 (基因名), Growth/differentiation factor 15 (蛋白名), gdf15_human.

产品名称:

Human GDF15/ Growth/differentiation factor 15 Recombinant Protein
生长分化因子15

货号:

R2034h

商标:

EIAab^®

监管等级:

RUO

别名:

Macrophage inhibitory cytokine 1, NSAID-activated gene 1 protein, NSAID-regulated gene 1 protein, Placental TGF-beta, Placental bone morphogenetic protein, Prostate differentiation factor, MIC-1, NAG-1, NRG-1, GDF-15, MIC1, PDF, PLAB, PTGFB

序列号:

Q99988

来源:

E.coli

种属:

Human

标签:

His

序列:

30-308aa

预估分子量:

30.69 kDa (monomer)

纯度:

Greater than 95% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Cancer

规格 & 价格:

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Human GDF15 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献 ( 2 )
出版物
序列 / 3D
常见问题解答
反馈墙 (0)

R&D 技术数据

The sequence analysis of human GDF15 protein including hydrophilcity, hydrophobicity and antigenicity.

Recombinant human GDF15 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: 19p13.11 by HGNC 19p13.11 by Entrez Gene 19p13.11 by Ensembl

GDF15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Homodimer; disulfide-linked (PubMed:29046435). Interacts with GFRAL; ligand of GFRAL which mediates GDF15 internalization and cellular signaling through interaction with RET (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099).

功能:

Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886). On hepatocytes, inhibits growth hormone signaling (By similarity).

亚细胞位置:

Secreted

数据库链接

UniGene:

Hs.616962

STRING:

9606.ENSP00000252809

KEGG:

hsa:9518

MIM:

605312

Pfam:

PF00019

Uniprot:

Q99988

相关产品

Mouse Gdf15 ELISA Kit

序列长度:

308

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

250:

300:

313:

YDDL LAKDC | HCI

3D 模型:

3D 结构:

免疫原序列:

验证序列:

[1].

"Role of YAP-related T cell imbalance and epidermal keratinocyte dysfunction in the pathogenesis of atopic dermatitis"

Jj Jia, Xm Mo, Fg Yan, et al.

From: Journal of Dermatological Science

[2].

"Growth Differentiation Factor 15 and Coronary Collateral Formation"

Tao Sun, ; Yanbo Huang, ; M. Ian Phillips, ; Xinping Luo, ; Jun Zhu,Haiming Shi, ; Jian Li,

From: Clinical Investigations

[1].

"Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53."

(PMID: 11895857)

[2].

"Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities."

(PMID: 11259636)

[3].

"Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family."

(PMID: 9593718)

[4].

"MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily."

(PMID: 9326641)

[5].

"PLAB, a novel placental bone morphogenetic protein."

(PMID: 9375789)

[6].

"GDF15 is a heart-derived hormone that regulates body growth."

(PMID: 28572090)

[7].

"GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates."

(PMID: 28846097)

[8].

"The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL."

(PMID: 28846098)

[9].

"GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand."

(PMID: 28846099)

[10].

"Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15."

(PMID: 28953886)

[1].

人生长分化因子15(GDF15)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人生长分化因子15(GDF15)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人生长分化因子15(GDF15)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人生长分化因子15(GDF15)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人生长分化因子15(GDF15)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人生长分化因子15(GDF15)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人生长分化因子15(GDF15)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人生长分化因子15(GDF15)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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