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GDF2 (基因名), Growth/differentiation factor 2 (蛋白名), gdf2_human.
产品名称:

Human GDF2/ Growth/differentiation factor 2 Recombinant Protein
生长和分化因子2

货号:

R1728h

商标:
EIAab®
监管等级:
别名:

Bone morphogenetic protein 9, BMP-9, GDF-2, BMP9

序列号:
Q9UK05
来源:
E.coli
种属:
Human
标签:
His
序列:
320-429aa
预估分子量:
12.1 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
  • Human GDF2 Protein
  • Human GDF2 Protein
  • Human GDF2 Protein
规格 & 价格: cart
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Human GDF2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human GDF2 Protein
The PCR product of human GDF2 gene was determined by 1% Agarose stained with EB.
Human GDF2 Protein
Recombinant human GDF2 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 10q11.22 by HGNC 10q11.22 by Entrez Gene 10q11.22 by Ensembl
GDF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer; disulfide-linked. Interacts with ENG.


功能:
Potent circulating inhibitor of angiogenesis. Could be involved in bone formation. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG.


亚细胞位置:
Secreted


该产品尚未在任何出版物中被引用。

[1].
"Bone morphogenetic protein-9 is a circulating vascular quiescence factor."

[2].
"Crystal structure of BMP-9 and functional interactions with pro-region and receptors."

[3].
"Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1."

[4].
"Structure of bone morphogenetic protein 9 procomplex."

[5].
"Regulation of bone morphogenetic protein 9 (BMP9) by redox-dependent proteolysis."

[6].
"BMP9 mutations cause a vascular-anomaly syndrome with phenotypic overlap with hereditary hemorrhagic telangiectasia."

[7].
"BMP9 is produced by hepatocytes and circulates mainly in an active mature form complexed to its prodomain."

[8].
"Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex."

[9].
"Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth."

[10].
"Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease."
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