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GGT1 (基因名), Glutathione hydrolase 1 proenzyme (蛋白名), ggt1_human1.
产品名称:

Human GGT1/ Glutathione hydrolase 1 proenzyme Recombinant Protein
γ谷氨酰转移酶1

货号:

R1375h

商标:
EIAab®
监管等级:
别名:

Gamma-glutamyltransferase 1, Gamma-glutamyltranspeptidase 1, Leukotriene-C4 hydrolase, GGT 1, CD224, GGT

序列号:
P19440
来源:
E.coli
种属:
Human
标签:
His
序列:
301-430aa
预估分子量:
14.3 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human GGT1 Protein
规格 & 价格: cart
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Human GGT1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human GGT1 Protein
Recombinant human GGT1 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 22q11.23 by HGNC 22q11.23 by Entrez Gene 22q11.23 by Ensembl
GGT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Heterodimer composed of the light and heavy chains. The active site is located in the light chain.


功能:
Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Isoform 3 seems to be inactive.


亚细胞位置:
Cell membrane Single-pass type II membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Gamma-glutamyl transpeptidase gene organization and expression: a comparative analysis in rat, mouse, pig and human species."

[2].
"Involvement of Ser-451 and Ser-452 in the catalysis of human gamma-glutamyl transpeptidase."

[3].
"Human gamma-glutamyl transpeptidase mutants involving conserved aspartate residues and the unique cysteine residue of the light subunit."

[4].
"Human GGT2 does not autocleave into a functional enzyme: A cautionary tale for interpretation of microarray data on redox signaling."

[5].
"Novel insights into eukaryotic γ-glutamyltranspeptidase 1 from the crystal structure of the glutamate-bound human enzyme."

[6].
"Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits."

[7].
"Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma."

[8].
"Analysis of site-specific glycosylation of renal and hepatic γ-glutamyl transpeptidase from normal human tissue."

[9].
"Pooling-based genome-wide association study implicates gamma-glutamyltransferase 1 (GGT1) gene in pancreatic carcinogenesis."

[10].
"Association of gamma-glutamyltransferase with incidence of type 2 diabetes in Japan."
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