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GHR (基因名), Growth hormone receptor (蛋白名), ghr_human.
产品名称:

Human GHR/ Growth hormone receptor Recombinant Protein
生长激素受体

货号:

R1036h

商标:
EIAab®
监管等级:
别名:

Somatotropin receptor, GH receptor

序列号:
P10912
来源:
E.coli
种属:
Human
标签:
His
序列:
CGYVSTDQLNKIMP
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human GHR Protein
规格 & 价格: cart
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Human GHR Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 5p13.1-p12 by HGNC 5p13.1-p12 by Entrez Gene 5p13.1-p12 by Ensembl
GHR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain. Binding to SOCS3 inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5 activation. Interacts with ADAM17.


功能:
Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.


亚细胞位置:
Growth hormone-binding protein Secreted Complexed to a substantial fraction of circulating GH.


该产品尚未在任何出版物中被引用。

[1].
"The growth hormone receptor (GHR) polymorphism in growth-retarded children with Cushing disease: lack of association with growth and measures of the somatotropic axis."

[2].
"The exon 3-deleted growth hormone receptor is associated with better response to pegvisomant therapy in acromegaly."

[3].
"Impact of the growth hormone receptor exon 3 deletion gene polymorphism on glucose metabolism, lipids, and insulin-like growth factor-I levels during puberty."

[4].
"Growth hormone receptor polymorphism and the effects of pegvisomant in acromegaly."

[5].
"The Leu544Ile polymorphism of the growth hormone receptor gene affects the serum cholesterol levels during GH treatment in children with GH deficiency."
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