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IFI30 (基因名), Gamma-interferon-inducible lysosomal thiol reductase (蛋白名), gilt_human.
产品名称:

Human IFI30/ Gamma-interferon-inducible lysosomal thiol reductase Recombinant Protein
γ-干扰素诱导溶酶体巯基还原

货号:

R11264h

商标:
EIAab®
监管等级:
别名:

Gamma-interferon-inducible protein IP-30, Legumaturain, GILT, IP30

序列号:
P13284
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human IFI30 Protein
规格 & 价格: cart
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Human IFI30 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 19p13.11 by HGNC 19p13.11 by Entrez Gene 19p13.11 by Ensembl
IFI30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Dimer; disulfide-linked.


功能:
Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation.


亚细胞位置:
Secreted Lysosome


该产品尚未在任何出版物中被引用。

[1].
"Enzymatic reduction of disulfide bonds in lysosomes: characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT)."

[2].
"Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action."

[3].
"Molecular and biochemical characterization of a novel gamma-interferon-inducible protein."

[4].
"Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling."

[5].
"Gamma-IFN-inducible-lysosomal thiol reductase modulates acidic proteases and HLA class II antigen processing in melanoma."

[6].
"Neuromyelitis optica/Devic's disease: gene expression profiling of brain lesions."

[7].
"Absence of gamma-interferon-inducible lysosomal thiol reductase in melanomas disrupts T cell recognition of select immunodominant epitopes."

[8].
"Role of the C-terminal propeptide in the activity and maturation of gamma -interferon-inducible lysosomal thiol reductase (GILT)."

[9].
"Multiple species express thiol oxidoreductases related to GILT."

[10].
"Autophagy-dependent crosstalk between GILT and PAX-3 influences radiation sensitivity of human melanoma cells."
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