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GLI1 (基因名), Zinc finger protein GLI1 (蛋白名), gli1_human1.
产品名称:

Human GLI1/ Zinc finger protein GLI1 Recombinant Protein
锌指蛋白GLI1

货号:

R15198h

商标:
EIAab®
监管等级:
别名:

Glioma-associated oncogene, Oncogene GLI, GLI

序列号:
P08151
来源:
E.coli
种属:
Human
标签:
His
序列:
222-400aa
预估分子量:
19.69 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human GLI1 Protein
规格 & 价格: cart
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Human GLI1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human GLI1 Protein
Recombinant human GLI1 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 12q13.3 by HGNC 12q13.3 by Entrez Gene 12q13.3 by Ensembl
GLI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with KIF7 (By similarity). Interacts with STK36 (PubMed:10806483). Interacts with ZIC1; the interaction enhances transcription activation (PubMed:11238441). Interacts with SUFU; this inhibits transcriptional activation by GLI1 (PubMed:10806483, PubMed:24311597, PubMed:24217340).


功能:
Isoform 2: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration.


亚细胞位置:
Isoform 2 Cytoplasm Nucleus


该产品尚未在任何出版物中被引用。

[1].
"Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation."

[2].
"A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion."

[3].
"GLI1 genotypes do not predict basal cell carcinoma risk: a case control study."

[4].
"Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways."

[5].
"Physical and functional interactions between Zic and Gli proteins."

[6].
"Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects."

[7].
"Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation."

[8].
"Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci."

[9].
"Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway."

[10].
"Expression of Gli1 correlates with the transition of breast cancer cells to estrogen-independent growth."
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