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GNAI1 (基因名), Guanine nucleotide-binding protein G(i) subunit alpha-1 (蛋白名), gnai1_chick.
产品名称:

Chicken GNAI1/ Guanine nucleotide-binding protein G(i) subunit alpha-1 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Adenylate cyclase-inhibiting G alpha protein

序列号:
P50146
来源:
E.coli
种属:
Chicken
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Chicken GNAI1 Protein
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Chicken GNAI1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Identified in complex with the beta subunit GNB1 and the gamma subunit GNG1. Identified in complex with the beta subunit GNB1 and the gamma subunit GNG2. GTP binding causes dissociation of the heterotrimer, liberating the individual subunits so that they can interact with downstream effector proteins.


功能:
Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels.


亚细胞位置:
Cytoplasm Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Membrane Lipid-anchor


该产品尚未在任何出版物中被引用。
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