首页 > 重组蛋白 > Human GNAS Recombinant Protein

GNAS (基因名), Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (蛋白名), gnas1_human.

产品名称:

Human GNAS/ Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Recombinant Protein
鸟嘌呤核苷酸结合蛋白G

货号:

R14288h

商标:

EIAab^®

监管等级:

RUO

别名:

Adenylate cyclase-stimulating G alpha protein, Extra large alphas protein, XLalphas, GNAS1

序列号:

Q5JWF2

来源:

E.coli

种属:

Human

标签:

His

序列:

11-230aa

预估分子量:

24.2 kDa (monomer)

纯度:

Greater than 90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Neurosciences

规格 & 价格:

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Human GNAS Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

Recombinant human GNAS protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: 20q13.32 by HGNC 20q13.32 by Entrez Gene 20q13.32 by Ensembl

GNAS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts through its N-terminal region with ALEX which is produced from the same locus in a different open reading frame. This interaction may inhibit its adenylyl cyclase-stimulating activity (By similarity). Interacts with MAGED2 (PubMed:27120771).

功能:

Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms.

亚细胞位置:

Cell membrane Peripheral membrane protein Apical cell membrane

数据库链接

UniGene:

Hs.125898

SMR:

Q5JWF2

STRING:

9606.ENSP00000360141

MIM:

139320

Pfam:

PF00503

Uniprot:

Q5JWF2

相关产品

Mouse Gnas ELISA Kit

Rat Gnas ELISA Kit

Bovine GNAS ELISA Kit

Pig GNAS ELISA Kit

Dog GNAS ELISA Kit

序列长度:

1037

序列:

仅供参考，详细请咨询（services@eiaab.com）

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1037:

YCYPHFTCAV | DTENIRRVFN | DCRDIIQRMH | LRQYELL

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Prevalence of TSH receptor and Gsalpha mutations in 45 autonomously functioning thyroid nodules in Japan."

(PMID: 19550078)

[2].

"Lack of involvement of the GNAS1 T393C polymorphism in prostate cancer risk in a Japanese population."

(PMID: 19189654)

[3].

"The T393C polymorphism in the gene GNAS1 of G protein is associated with survival of patients with invasive breast carcinoma."

(PMID: 17186357)

[4].

"Molecular analysis of the GNAS1 gene for the correct diagnosis of Albright hereditary osteodystrophy and pseudohypoparathyroidism."

(PMID: 12621129)

[5].

"An imprinted antisense transcript at the human GNAS1 locus."

(PMID: 10749992)

[6].

"Neuroendocrine secretory protein 55 (NESP55): alternative splicing onto transcripts of the GNAS gene and posttranslational processing of a maternally expressed protein."

(PMID: 10729789)

[7].

"Bidirectional imprinting of a single gene: GNAS1 encodes maternally, paternally, and biallelically derived proteins."

(PMID: 9860993)

[8].

"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

(PMID: 20628086)

[9].

"Human variation in alcohol response is influenced by variation in neuronal signaling genes."

(PMID: 20201926)

[10].

"Association study of 182 candidate genes in anorexia nervosa."

(PMID: 20468064)

[1].

人鸟嘌呤核苷酸结合蛋白G(GNAS)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人鸟嘌呤核苷酸结合蛋白G(GNAS)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人鸟嘌呤核苷酸结合蛋白G(GNAS)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人鸟嘌呤核苷酸结合蛋白G(GNAS)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人鸟嘌呤核苷酸结合蛋白G(GNAS)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人鸟嘌呤核苷酸结合蛋白G(GNAS)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人鸟嘌呤核苷酸结合蛋白G(GNAS)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人鸟嘌呤核苷酸结合蛋白G(GNAS)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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