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GSDMC (基因名), Gasdermin-C (蛋白名), gsdmc_human.
产品名称:

Human GSDMC/ Gasdermin-C Recombinant Protein
Gasdermin-C

货号:

R1646h

商标:
EIAab®
监管等级:
别名:

Melanoma-derived leucine zipper-containing extranuclear factor, MLZE

序列号:
Q9BYG8
来源:
E.coli
种属:
Human
标签:
His
序列:
1-150aa
预估分子量:
16.5 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human GSDMC Protein
规格 & 价格: cart
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Human GSDMC Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human GSDMC Protein
Recombinant human GSDMC protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 8q24.21 by HGNC 8q24.21 by Entrez Gene 8q24.21 by Ensembl
GSDMC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
The N-terminal moiety forms homooligomer; disulfide-linked. May form an 16-mer complex. Oligomerization occurs in the presence of membranes.


功能:
The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores (PubMed:27281216). The physiological relevance of this observation is unknown.


亚细胞位置:
Cytoplasm Cytosol Cell membrane


该产品尚未在任何出版物中被引用。

[1].
"Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner."

[2].
"Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium."

[3].
"Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24."

[4].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[5].
"Structure, expression and chromosome mapping of MLZE, a novel gene which is preferentially expressed in metastatic melanoma cells."

[6].
"Gasdermin C is induced by ultraviolet light and contributes to MMP-1 expression via activation of ERK and JNK pathways."

[7].
"Pore-forming activity and structural autoinhibition of the gasdermin family."

[8].
"Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor β Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation."

[9].
"A novel common variant in DCST2 is associated with length in early life and height in adulthood."

[10].
"Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci."
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