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HASPIN (基因名), Serine/threonine-protein kinase haspin (蛋白名), hasp_human.
产品名称:

Human HASPIN/ Serine/threonine-protein kinase haspin Recombinant Protein

货号:

R2774h

商标:
EIAab®
监管等级:
别名:

Germ cell-specific gene 2 protein, H-haspin, Haploid germ cell-specific nuclear protein kinase, GSG2

序列号:
Q8TF76
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human HASPIN Protein
规格 & 价格: cart
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Human HASPIN Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 17p13.2 by HGNC 17p13.2 by Entrez Gene 17p13.2 by Ensembl
HASPIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
N/A


功能:
Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.


亚细胞位置:
Nucleus Chromosome Cytoplasm Cytoskeleton Spindle Nuclear during interphase and associates with the chromosomes and spindle apparatus during mitosis.


该产品尚未在任何出版物中被引用。

[1].
"Regulation of mitotic chromosome cohesion by Haspin and Aurora B."

[2].
"The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment."

[3].
"Cloning and characterization of human haspin gene encoding haploid germ cell-specific nuclear protein kinase."

[4].
"The Haspin gene: location in an intron of the integrin alphaE gene, associated transcription of an integrin alphaE-derived RNA and expression in diploid as well as haploid cells."

[5].
"Structure, Roles and Inhibitors of a Mitotic Protein Kinase Haspin."

[6].
"A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosis."

[7].
"Haspin: a newly discovered regulator of mitotic chromosome behavior."

[8].
"Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis."

[9].
"Two histone marks establish the inner centromere and chromosome bi-orientation."

[10].
"Studies of haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion."
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