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HCLS1 (基因名), Hematopoietic lineage cell-specific protein (蛋白名), hcls1_human.
产品名称:

Human HCLS1/ Hematopoietic lineage cell-specific protein Recombinant Protein

货号:

R15649h

商标:
EIAab®
监管等级:
别名:

Hematopoietic cell-specific LYN substrate 1, LckBP1, p75, HS1

序列号:
P14317
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human HCLS1 Protein
规格 & 价格: cart
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Human HCLS1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 3q13.33 by HGNC 3q13.33 by Entrez Gene 3q13.33 by Ensembl
HCLS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3. Interacts with FES/FPS (By similarity). Interacts (via SH2 domain) with FGR. Forms a multiprotein complex with LYN and ANKRD54.


功能:
Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.


亚细胞位置:
Membrane Peripheral membrane protein Cytoplasm Mitochondrion


该产品尚未在任何出版物中被引用。

[1].
"Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain."

[2].
"Association of a four-amino acid residue insertion polymorphism of the HS1 gene with systemic lupus erythematosus: molecular and functional analysis."

[3].
"Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase."

[4].
"The human HCLS1 gene maps to chromosome 3q13 by fluorescence in situ hybridization."

[5].
"Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling."
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