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HCN2 (基因名), Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (蛋白名), hcn2_human.
产品名称:

Human HCN2/ Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Recombinant Protein
钾/钠超极化激活环核苷酸门控通道蛋白2

货号:

R15069h

商标:
EIAab®
监管等级:
别名:

Brain cyclic nucleotide-gated channel 2, BCNG-2, BCNG2

序列号:
Q9UL51
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human HCN2 Protein
规格 & 价格: cart
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Human HCN2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 19p13.3 by HGNC 19p13.3 by Entrez Gene 19p13.3 by Ensembl
HCN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming subunits. Heterotetramer with HCN1. Forms an obligate 4:4 complex with accessory subunit PEX5L. Interacts with KCNE2 (By similarity). Homotetramer.


功能:
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.


亚细胞位置:
Cell membrane Multi-pass membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Two pacemaker channels from human heart with profoundly different activation kinetics."

[2].
"Augmented currents of an HCN2 variant in patients with febrile seizure syndromes."

[3].
"Mutation analysis of the hyperpolarization-activated cyclic nucleotide-gated channels HCN1 and HCN2 in idiopathic generalized epilepsy."

[4].
"Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain."

[5].
"Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels."

[6].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[7].
"Hyperpolarization-activated cation channels: from genes to function."

[8].
"Novel mechanism for suppression of hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by receptor-like tyrosine phosphatase-alpha."

[9].
"Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels."

[10].
"Cooperative gating between single HCN pacemaker channels."
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