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首页  >  重组蛋白  >  Human HCN4 Recombinant Protein
HCN4 (基因名), Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (蛋白名), hcn4_human.
产品名称:

Human HCN4/ Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Recombinant Protein
钾/钠超极化激活环核苷酸门控通道蛋白4

货号:

R13654h

商标:
EIAab®
监管等级:
序列号:
Q9Y3Q4
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human HCN4 Protein
规格 & 价格: cart
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Human HCN4 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 15q24.1 by HGNC 15q24.1 by Entrez Gene 15q24.1 by Ensembl
HCN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homotetramer. The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming subunits.


功能:
Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli.


亚细胞位置:
Cell membrane Multi-pass membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Role of HCN4 channel in preventing ventricular arrhythmia."

[2].
"Two pacemaker channels from human heart with profoundly different activation kinetics."

[3].
"Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis."

[4].
"Local and global interpretations of a disease-causing mutation near the ligand entry path in hyperpolarization-activated cAMP-gated channel."

[5].
"Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels."

[6].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[7].
"A novel mutation in the HCN4 gene causes symptomatic sinus bradycardia in Moroccan Jews."

[8].
"Novel pharmacological activity of loperamide and CP-339,818 on human HCN channels characterized with an automated electrophysiology assay."

[9].
"Point mutation in the HCN4 cardiac ion channel pore affecting synthesis, trafficking, and functional expression is associated with familial asymptomatic sinus bradycardia."

[10].
"Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel."
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