首页 > 重组蛋白 > Human HDAC6 Recombinant Protein

HDAC6 (基因名), Histone deacetylase 6 (蛋白名), hdac6_human.

产品名称:

Human HDAC6/ Histone deacetylase 6 Recombinant Protein
组蛋白脱乙酰酶6

货号:

R11377h

商标:

EIAab^®

监管等级:

RUO

别名:

JM21, HD6, KIAA0901

序列号:

Q9UBN7

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Cancer

规格 & 价格:

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Human HDAC6 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: Xp11.23 by HGNC Xp11.23 by Entrez Gene Xp11.23 by Ensembl

HDAC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with ZMYND15 (By similarity). Interacts with SIRT2 (via both phosphorylated, unphosphorylated, active or inactive forms); the interaction is necessary for the complex to interact with alpha-tubulin. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with BBIP10, CBFA2T3, CYLD, DDIT3/CHOP, F-actin and HDAC11. Interacts with FAM65B (PubMed:24687993).

功能:

In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.

亚细胞位置:

Nucleus Cytoplasm Perikaryon Cell projection Dendrite Cell projection Axon It is mainly cytoplasmic, where it is associated with microtubules.

数据库链接

UniGene:

Hs.6764

SMR:

Q9UBN7

STRING:

9606.ENSP00000334061

KEGG:

hsa:10013

MIM:

300272

Pfam:

PF00850

Uniprot:

Q9UBN7

相关产品

Mouse Hdac6 ELISA Kit

Mouse Hdac6 CLIA Kit

Mouse Hdac6 Protein

Mouse Hdac6 Polyclonal Antibody

Mouse Hdac6 Monoclonal Antibody

序列长度:

1215

序列:

仅供参考，详细请咨询（services@eiaab.com）

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1215:

IAHQNKFGED | MPHPH

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Three proteins define a class of human histone deacetylases related to yeast Hda1p."

(PMID: 10220385)

[2].

"Requirement of a novel splicing variant of human histone deacetylase 6 for TGF-beta1-mediated gene activation."

(PMID: 20102703)

[3].

"CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin."

(PMID: 19893491)

[4].

"The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition."

(PMID: 19033385)

[5].

"HEF1-dependent Aurora A activation induces disassembly of the primary cilium."

(PMID: 17604723)

[6].

"Mutations in SIRT2 deacetylase which regulate enzymatic activity but not its interaction with HDAC6 and tubulin."

(PMID: 17516032)

[7].

"HDAC6 is a microtubule-associated deacetylase."

(PMID: 12024216)

[8].

"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."

(PMID: 10048485)

[9].

"Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1."

(PMID: 24413532)

[10].

"Fam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiation."

(PMID: 24687993)

[1].

人组蛋白脱乙酰酶6(HDAC6)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人组蛋白脱乙酰酶6(HDAC6)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人组蛋白脱乙酰酶6(HDAC6)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人组蛋白脱乙酰酶6(HDAC6)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人组蛋白脱乙酰酶6(HDAC6)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人组蛋白脱乙酰酶6(HDAC6)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人组蛋白脱乙酰酶6(HDAC6)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人组蛋白脱乙酰酶6(HDAC6)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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