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HDAC9 (基因名), Histone deacetylase 9 (蛋白名), hdac9_human.
产品名称:

Human HDAC9/ Histone deacetylase 9 Recombinant Protein
组蛋白脱乙酰酶9

货号:

R11380h

商标:
EIAab®
监管等级:
别名:

Histone deacetylase 7B, Histone deacetylase-related protein, MEF2-interacting transcription repressor MITR, HD7, HD9, HDAC7, HDAC7B, HDRP, KIAA0744, MITR

序列号:
Q9UKV0
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human HDAC9 Protein
规格 & 价格: cart
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Human HDAC9 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 7p21.1 by HGNC 7p21.1 by Entrez Gene 7p21.1 by Ensembl
HDAC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer. Interacts with CTBP1. The phosphorylated form interacts with 14-3-3 (By similarity). Interacts with HDAC1 and HDAC3, and probably with HDAC4 and HDAC5. Interacts with MEF2, MAPK10, ETV6, NCOR1 and BCL6. Interacts with FOXP3 in the absence of T-cell stimulation.


功能:
Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.


亚细胞位置:
Nucleus


该产品尚未在任何出版物中被引用。

[1].
"The histone deacetylase 9 gene encodes multiple protein isoforms."

[2].
"Cloning and characterization of a histone deacetylase, HDAC9."

[3].
"Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5."

[4].
"MEF-2 function is modified by a novel co-repressor, MITR."

[5].
"HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor."
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