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HEPACAM (基因名), Hepatocyte cell adhesion molecule (蛋白名), hecam_human.
产品名称:

Human HEPACAM/ Hepatocyte cell adhesion molecule Recombinant Protein

货号:

R11096h

商标:
EIAab®
监管等级:
别名:

Protein hepaCAM

序列号:
Q14CZ8
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human HEPACAM Protein
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Human HEPACAM Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 11q24.2 by HGNC 11q24.2 by Entrez Gene 11q24.2 by Ensembl
HEPACAM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer. Dimer formation occurs predominantly through cis interactions on the cell surface. Part of a complex containing MLC1, TRPV4, AQP4 and ATP1B1.


功能:
Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation.


亚细胞位置:
Cytoplasm Membrane Single-pass type I membrane protein Cytoplasmic side In MCF-7 breast carcinoma and hepatic Hep 3B2.1-7 and Hep-G2 cell lines, localization of HEPACAM is cell density-dependent. In well spread cells, localized to punctate structures in the perinuclear membrane, cytoplasm, and at cell surface of protusions. In confluent cells, localized predominantly to the cytoplasmic membrane, particularly in areas of cell-cell contacts. Colocalizes with CDH1.


该产品尚未在任何出版物中被引用。

[1].
"Cloning and characterization of hepaCAM, a novel Ig-like cell adhesion molecule suppressed in human hepatocellular carcinoma."

[2].
"Structural and functional analyses of a novel ig-like cell adhesion molecule, hepaCAM, in the human breast carcinoma MCF7 cells."

[3].
"Mutant GlialCAM causes megalencephalic leukoencephalopathy with subcortical cysts, benign familial macrocephaly, and macrocephaly with retardation and autism."

[4].
"HepaCAM inhibits the malignant behavior of castration-resistant prostate cancer cells by downregulating Notch signaling and PF-3084014 (a γ-secretase inhibitor) partly reverses the resistance of refractory prostate cancer to docetaxel and enzalutamide in vitro."

[5].
"Overexpression of Hepatocyte Cell Adhesion Molecule (hepaCAM) Inhibits the Proliferation, Migration, and Invasion in Colorectal Cancer Cells."

[6].
"Architecture of the human interactome defines protein communities and disease networks."

[7].
"Interleukin 6 induces cell proliferation of clear cell renal cell carcinoma by suppressing hepaCAM via the STAT3-dependent up-regulation of DNMT1 or DNMT3b."

[8].
"Overexpression of HepaCAM inhibits bladder cancer cell proliferation and viability through the AKT/FoxO pathway."

[9].
"HEPACAM inhibited the growth and migration of cancer cells in the progression of non-small cell lung cancer."

[10].
"HepaCAM associates with connexin 43 and enhances its localization in cellular junctions."
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