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HELQ (基因名), Helicase POLQ-like (蛋白名), helq_human.
产品名称:

Human HELQ/ Helicase POLQ-like Recombinant Protein

货号:

R4683h

商标:
EIAab®
监管等级:
别名:

Mus308-like helicase, POLQ-like helicase, HEL308

序列号:
Q8TDG4
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human HELQ Protein
规格 & 价格: cart
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Human HELQ Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 4q21.23 by HGNC 4q21.23 by Entrez Gene 4q21.23 by Ensembl
HELQ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Hexamer (PubMed:11751861). Interacts with POLN (PubMed:19995904).


功能:
Single-stranded DNA-dependent ATPase and 5' to 3' DNA helicase (PubMed:11751861). Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with POLN polymerase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links (PubMed:19995904).


亚细胞位置:
N/A


该产品尚未在任何出版物中被引用。

[1].
"A human DNA helicase homologous to the DNA cross-link sensitivity protein Mus308."

[2].
"Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways."

[3].
"A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium."

[4].
"DNA polymerase POLN participates in cross-link repair and homologous recombination."

[5].
"Helicase POLQ-like (HELQ) as a novel indicator of platinum-based chemoresistance for epithelial ovarian cancer."

[6].
"HELQ reverses the malignant phenotype of osteosarcoma cells via CHK1-RAD51 signaling pathway."

[7].
"DNA binding and unwinding by Hel308 helicase requires dual functions of a winged helix domain."

[8].
"Screening of HELQ in breast and ovarian cancer families."

[9].
"Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing."

[10].
"The screening of HELQ gene in Chinese patients with premature ovarian failure."
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