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HAMP (基因名), Hepcidin (蛋白名), hepc_human.
产品名称:

Human HAMP/ Hepcidin Recombinant Protein
Hepcidin

货号:

R1979h

商标:
EIAab®
监管等级:
别名:

Liver-expressed antimicrobial peptide 1, Putative liver tumor regressor, LEAP-1, PLTR, UNQ487/PRO1003, HEPC, LEAP1

序列号:
P81172
来源:
E.coli
种属:
Human
标签:
His
序列:
1-84aa
预估分子量:
9.24 kDa (monomer)
纯度:
Greater than 90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human HAMP Protein
规格 & 价格: cart
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Human HAMP Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
Human HAMP Protein
Recombinant human HAMP protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 19q13.12 by HGNC 19q13.12 by Entrez Gene 19q13.12 by Ensembl
HAMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
N/A


功能:
Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa (PubMed:11113131, PubMed:11034317).


亚细胞位置:
Secreted



[1].
"HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype."

[2].
"Association of hepcidin promoter c.-582 A>G variant and iron overload in thalassemia major."

[3].
"Mutations in HAMP and HJV genes and their impact on expression of clinical hemochromatosis in a cohort of 100 Spanish patients homozygous for the C282Y mutation of HFE gene."

[4].
"Non-classical hereditary hemochromatosis in Portugal: novel mutations identified in iron metabolism-related genes."

[5].
"Common variants in the BMP2, BMP4, and HJV genes of the hepcidin regulation pathway modulate HFE hemochromatosis penetrance."

[6].
"Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis."

[7].
"The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis."

[8].
"A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload."

[9].
"Hepcidin, a urinary antimicrobial peptide synthesized in the liver."

[10].
"LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity."
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