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HMCES (基因名), Abasic site processing protein HMCES (蛋白名), hmces_chick.
产品名称:

Chicken HMCES/ Abasic site processing protein HMCES Recombinant Protein
胚胎干细胞特异性5-羟甲基胞嘧啶结合蛋白

货号:

R15335c

商标:
EIAab®
监管等级:
别名:

Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein, Peptidase HMCES, Putative endonuclease HMCES, SRAP domain-containing protein 1, ES cell-specific 5hmC-binding protein, RCJMB04_15p13, SRAPD1

序列号:
Q5ZJT1
来源:
E.coli
种属:
Chicken
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Chicken HMCES Protein
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Chicken HMCES Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
N/A


功能:
Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (By similarity). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells. May act as an endonuclease that specifically cleaves 5hmC-containing DNA; additional experiments are however required to confirm this activity in vivo (By similarity).


亚细胞位置:
Chromosome Recruited to chromatin following DNA damage. Localizes to replication forks.


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