首页 > 重组蛋白 > Human HSPA1A Recombinant Protein

HSPA1A (基因名), Heat shock 70 kDa protein 1A/1B (蛋白名), hsp71_human.

产品名称:

Human HSPA1A/ Heat shock 70 kDa protein 1A/1B Recombinant Protein
热休克70 kDa蛋白

货号:

R0873h

商标:

EIAab^®

监管等级:

RUO

别名:

Heat shock 70 kDa protein 1/2, HSP70-1/HSP70-2, HSP70.1/HSP70.2, HSPA1, HSX70

序列号:

P08107

来源:

E.coli

种属:

Human

标签:

His

序列:

415-540aa

预估分子量:

13.86 kDa (monomer)

纯度:

Greater than 95% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Neurosciences

规格 & 价格:

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产品说明书

说明书:

MSDS:

在线询价

数据
文献 ( 2 )
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

The PCR product of human HSPA1A gene was determined by 1% Agarose stained with EB.

Recombinant human HSPA1A protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.

基因位点

Cytogenetic band: 6p21.33 by HGNC 6p21.33 by Entrez Gene 6p21.33 by Ensembl

HSPA1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Component of a complex composed at least of CATSPER1, CATSPERB, CATSPERG and HSPA1B (By similarity). Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with TSC2. Interacts with IRAK1BP1. Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed. Interacts with DNAJC7. Interacts with CHCHD3.

功能:

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.

亚细胞位置:

Cytoplasm Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

数据库链接

Uniprot:

P08107

相关产品

Mouse Hspa1a ELISA Kit

Rat Hspa1a ELISA Kit

Bovine HSPA1A ELISA Kit

Pig HSPA1A ELISA Kit

Mouse Hspa1a CLIA Kit

序列长度:

641

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

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641:

QVCNPIISGL | YQGAGGPGPG | GFGAQGPKGG | SGSGPTIEEV | D

3D 模型:

3D 结构:

免疫原序列:

验证序列:

[1].

"Proteomic analysis reveals significant elevation of heat shock protein 70 in patients with chronic heart failure due to arrhythmogenic right ventricul"

Ying-Jie Wei, Yin-Xia Huang, Ya Shen, Chuan-Jue Cui, Xiao-Ling Zhang, Hao Zhang, Sheng-Shou Hu

From: Molecular and Cellular Biochemistry

[2].

"Evaluation of serum heat shock protein 70 concentration in women with recurrent miscarriages"

L Nowak-Los, et al.

From: Folia Medica Copernicana

[1].

"Polymorphic analysis of the heat-shock protein 70 gene (HSPA1A) in Ménière's disease."

(PMID: 19241595)

[2].

"The septic shock associated HSPA1B1267 polymorphism influences production of HSPA1A and HSPA1B."

(PMID: 15232679)

[3].

"ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation."

(PMID: 27708256)

[4].

"A novel nuclear DnaJ protein, DNAJC8, can suppress the formation of spinocerebellar ataxia 3 polyglutamine aggregation in a J-domain independent manner."

(PMID: 27133716)

[5].

"HSP70 regulates the function of mitotic centrosomes."

(PMID: 27137183)

[6].

"Hsp70 and Hsp90 oppositely regulate TGF-β signaling through CHIP/Stub1."

(PMID: 24613385)

[7].

"Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro."

(PMID: 24318877)

[8].

"RING finger protein RNF207, a novel regulator of cardiac excitation."

(PMID: 25281747)

[9].

"The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease."

(PMID: 24790089)

[10].

"A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity."

(PMID: 23349634)

[1].

人热休克70 kDa蛋白(HSPA1A)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人热休克70 kDa蛋白(HSPA1A)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人热休克70 kDa蛋白(HSPA1A)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人热休克70 kDa蛋白(HSPA1A)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人热休克70 kDa蛋白(HSPA1A)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人热休克70 kDa蛋白(HSPA1A)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人热休克70 kDa蛋白(HSPA1A)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人热休克70 kDa蛋白(HSPA1A)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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