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HYAL2 (基因名), Hyaluronidase-2 (蛋白名), hyal2_human.
产品名称:

Human HYAL2/ Hyaluronidase-2 Recombinant Protein
Hyal-2

货号:

R1126h

商标:
EIAab®
监管等级:
别名:

Hyaluronoglucosaminidase-2, Lung carcinoma protein 2, LuCa-2, Hyal-2, LUCA2

序列号:
Q12891
来源:
E.coli
种属:
Human
标签:
His
序列:
Recombinant Protein
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Signal Transduction
Human HYAL2 Protein
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Human HYAL2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 3p21.31 by HGNC 3p21.31 by Entrez Gene 3p21.31 by Ensembl
HYAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with MST1R.


功能:
Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.


亚细胞位置:
Cell membrane Lipid-anchor GPI-anchor


该产品尚未在任何出版物中被引用。

[1].
"HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity."

[2].
"Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus."

[3].
"Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation."

[4].
"Hyal2--less active, but more versatile?"

[5].
"Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase."

[6].
"Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYAL1 and hyaluronan content."

[7].
"bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells."

[8].
"Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines."

[9].
"HYAL1 and HYAL2 inhibit tumour growth in vivo but not in vitro."

[10].
"[Down-regulation of RBSP3/CTDSPL, NPRL2/G21, RASSF1A, ITGA9, HYAL1 and HYAL2 genes in non-small cell lung cancer]."
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