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SERPING1 (基因名), Plasma protease C1 inhibitor (蛋白名), ic1_human.
产品名称:

Human SERPING1/ Plasma protease C1 inhibitor Recombinant Protein
血浆蛋白C1抑制剂

货号:

R0235h

商标:
EIAab®
监管等级:
别名:

C1 esterase inhibitor, C1-inhibiting factor, Serpin G1, C1 Inh, C1IN, C1NH

序列号:
P05155
来源:
E.coli
种属:
Human
标签:
His
序列:
84-138aa
预估分子量:
6.05 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Immunology
Human SERPING1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 11q12.1 by HGNC 11q12.1 by Entrez Gene 11q12.1 by Ensembl
SERPING1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Interacts with MASP1.


功能:
Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.


亚细胞位置:
Secreted


该产品尚未在任何出版物中被引用。

[1].
"The functional integrity of the serpin domain of C1-inhibitor depends on the unique N-terminal domain, as revealed by a pathological mutant."

[2].
"Mutation screening of the C1 inhibitor gene among Hungarian patients with hereditary angioedema."

[3].
"Mutations in the C1 inhibitor gene that result in hereditary angioneurotic edema."

[4].
"Complete nucleotide sequence of the gene for human C1 inhibitor with an unusually high density of Alu elements."

[5].
"Mutational spectrum of the c1 inhibitor gene in a cohort of Italian patients with hereditary angioedema: description of nine novel mutations."

[6].
"Update of the human and mouse SERPIN gene superfamily."

[7].
"Mutational spectrum and geno-phenotype correlation in Chinese families with hereditary angioedema."

[8].
"Novel and recurrent mutations in the C1NH gene of Arab patients affected with hereditary angioedema."

[9].
"Polymorphisms in PARP, IL1B, IL4, IL10, C1INH, DEFB1, and DEFA4 in meningococcal disease in three populations."

[10].
"An association study of SERPING1 gene and age-related macular degeneration in a Han Chinese population."
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