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IER3 (基因名), Radiation-inducible immediate-early gene IEX-1 (蛋白名), iex1_human.
产品名称:

Human IER3/ Radiation-inducible immediate-early gene IEX-1 Recombinant Protein
辐射诱导即早基因IEX-1

货号:

R12474h

商标:
EIAab®
监管等级:
别名:

Differentiation-dependent gene 2 protein, Immediate early protein GLY96, Immediate early response 3 protein, PACAP-responsive gene 1 protein, Protein DIF-2, Protein PRG1, DIF2, IEX1, PRG1

序列号:
P46695
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human IER3 Protein
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Human IER3 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 6p21.33 by HGNC 6p21.33 by Entrez Gene 6p21.33 by Ensembl
IER3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with the PPP2R5C-PP2A holoenzyme and ERK kinases; regulates ERK dephosphorylation.


功能:
May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.


亚细胞位置:
Membrane Single-pass type II membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Identification and characterization of a radiation-inducible glycosylated human early-response gene."

[2].
"B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK."

[3].
"IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation."

[4].
"Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection."

[5].
"High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions."

[6].
"Overexpression of immediate early gene X-1 (IEX-1) enhances gamma-radiation-induced apoptosis of human glioma cell line, U87-MG."

[7].
"Differential gene expression of bone marrow-derived CD34+ cells is associated with survival of patients suffering from myelodysplastic syndrome."

[8].
"IEX-1-induced cell death requires BIM and is modulated by MCL-1."

[9].
"Rearrangements and amplification of IER3 (IEX-1) represent a novel and recurrent molecular abnormality in myelodysplastic syndromes."

[10].
"TP53 R72P and MDM2 SNP309 polymorphisms in modification of childhood acute lymphoblastic leukemia susceptibility."
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