首页 > 重组蛋白 > Human IFIT1 Recombinant Protein

IFIT1 (基因名), Interferon-induced protein with tetratricopeptide repeats 1 (蛋白名), ifit1_human.

产品名称:

Human IFIT1/ Interferon-induced protein with tetratricopeptide repeats 1 Recombinant Protein
带肽重复序列结构域1的干扰素诱导表达蛋白

货号:

R14985h

商标:

EIAab^®

监管等级:

RUO

别名:

Interferon-induced 56 kDa protein, IFI-56K, IFIT-1, G10P1, IFI56, IFNAI1, ISG56

序列号:

P09914

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

规格 & 价格:

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Human IFIT1 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 10q23.31 by HGNC 10q23.31 by Entrez Gene 10q23.31 by Ensembl

IFIT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3. Interacts (via TPR repeats 4-7) with EEF1A1 (By similarity). Interacts with EIF3C (By similarity). Interacts with IFIT2 and IFIT3. Interacts (via TPR repeats 1-4) with RPL15. Interacts with TMEM173/MITA and disrupts its interaction with MAVS or TBK1. Interacts with EIF3E. Interacts (via TPR repeat 2) with E1 proteins of HPV types 11, 18 and 3 and this interaction blocks E1 helicase activity and viral replication.

功能:

Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.

亚细胞位置:

Cytoplasm

数据库链接

UniGene:

Hs.20315

SMR:

P09914

STRING:

9606.ENSP00000360869

KEGG:

hsa:3434

MIM:

147690

Pfam:

PF13181

Uniprot:

P09914

相关产品

Mouse Ifit1 ELISA Kit

Mouse Ifit1 CLIA Kit

Mouse Ifit1 Protein

Mouse Ifit1 Polyclonal Antibody

Mouse Ifit1 Monoclonal Antibody

序列长度:

478

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

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250:

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450:

478:

GNMNEALEYY | ERALRLAADF | ENSVRQGP

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"The interferon- and virus-inducible IFI-56K and IFI-54K genes are located on human chromosome 10 at bands q23-q24."

(PMID: 1377167)

[2].

"The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family."

(PMID: 3360121)

[3].

"Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins."

(PMID: 23334420)

[4].

"The interferon stimulated gene 54 promotes apoptosis."

(PMID: 21190939)

[5].

"The ISG56/IFIT1 gene family."

(PMID: 20950130)

[6].

"A novel interaction between interferon-inducible protein p56 and ribosomal protein L15 in gastric cancer cells."

(PMID: 21612406)

[7].

"IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA."

(PMID: 21642987)

[8].

"ISG56 and IFITM1 proteins inhibit hepatitis C virus replication."

(PMID: 21976647)

[9].

"Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"."

(PMID: 20628624)

[10].

"ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response."

(PMID: 19416887)

[1].

人带肽重复序列结构域1的干扰素诱导表达蛋白(IFIT1)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人带肽重复序列结构域1的干扰素诱导表达蛋白(IFIT1)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人带肽重复序列结构域1的干扰素诱导表达蛋白(IFIT1)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人带肽重复序列结构域1的干扰素诱导表达蛋白(IFIT1)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人带肽重复序列结构域1的干扰素诱导表达蛋白(IFIT1)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人带肽重复序列结构域1的干扰素诱导表达蛋白(IFIT1)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人带肽重复序列结构域1的干扰素诱导表达蛋白(IFIT1)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人带肽重复序列结构域1的干扰素诱导表达蛋白(IFIT1)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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