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Ifit3 (基因名), Interferon-induced protein with tetratricopeptide repeats 3 (蛋白名), ifit3_mouse.
产品名称:

Mouse Ifit3/ Interferon-induced protein with tetratricopeptide repeats 3 Recombinant Protein
具有四肽重复序列的干扰素诱导蛋白

货号:

R2804m

商标:
EIAab®
监管等级:
别名:

Glucocorticoid-attenuated response gene 49 protein, IRG2, GARG-49, IFIT-3, Garg49, Ifi49, Isg49

序列号:
Q64345
来源:
E.coli
种属:
Mouse
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Immunology
Mouse Ifit3 Protein
规格 & 价格: cart
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Mouse Ifit3 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
通用注释


亚单元:
Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3. Interacts with IFIT1 and IFIT2 (By similarity). Interacts (via N-terminus) with MAVS, TBK1, TRAF6 and DDX58 (By similarity). Interacts with COPS5.


功能:
IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.


亚细胞位置:
Cytoplasm Mitochondrion


该产品尚未在任何出版物中被引用。
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